Best Enterprise Patient Portal Software
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Compare the Top Enterprise Patient Portal Software as of April 2026
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What is Enterprise Patient Portal Software?
Patient portal software provides a secure online platform where patients can access their personal health information, communicate with healthcare providers, and manage appointments. It offers features such as viewing test results, requesting prescription refills, messaging doctors, and scheduling visits, enhancing patient convenience and engagement. By integrating with electronic health records (EHR) systems, the portal ensures up-to-date and accurate medical data access. This software empowers patients to take a more active role in their healthcare, improving transparency and satisfaction. Additionally, it reduces administrative burdens on staff by automating routine tasks and facilitating better communication. Compare and read user reviews of the best Enterprise Patient Portal software currently available using the table below. This list is updated regularly.
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1
RXNT
RXNT
RXNT is an ambulatory healthcare technology pioneer that empowers medical practices and healthcare organizations to succeed and scale through innovative, data-backed, AI-powered software. Our fully-integrated, ONC-certified suite of medical software—like Clinical EHRs, Practice Management, Medical Billing and RCM, E-Prescribing, Practice Scheduling, Patient Portal, and more—optimizes clinical outcomes and RCM for your practice. Used by tens of thousands of medical professionals—from large physician practices to medical billing companies—to drive growth, streamline business operations, and improve patient care across all 50 U.S. states. Our unified “Full Suite” system employs a secure, central database so your data passes through every product in real-time from anywhere, and more than 125 million prescriptions have been transmitted and over $7 billion in claims have been processed using RXNT.Starting Price: $118/month -
2
Ensora Mental Health
TheraNest
For solo and small-group mental health practice owners, TheraNest is the EHR and practice-management platform that simplifies clinical documentation, streamlines billing, and empowers sustainable practice growth without administrative headaches. Unlike SimplePractice and TherapyNotes, TherapyNotes uniquely allows therapists to run secure group telehealth sessions (up to 20 participants), automatically insert evidence-based Wiley® treatment plans, and access built-in flat-rate RCM services — all in one place. TheraNest gives therapists back time, control, and confidence by combining workflow automation, AI-enhanced documentation, and reliable U.S.-based support.Starting Price: $29 per month -
3
Mercury One Plus
CrisSoft
Mercury One Plus is a Medical Practice Management solution that puts the fundamentals of Revenue Cycle Management at your fingertips; it acts as a stepping stone from standard billing to intermediate billing. Mercury One Plus is offered exclusively on the cloud, with the highest level of security- you can access your data anywhere 24/7. A complete product with big functionality, Mercury One Plus includes: patient demographics input, 100 plus reports to choose from, charge entry, full history of patient activity, ERA posting, credit card acceptance, and much more. Mercury Products are HIPAA compliant with a guaranteed connection to any clearinghouse or insurance company. Mercury One Plus's automated job system will facilitate a daily system tune-up: housecleaning; folder maintenance; daily backups; 837 exports; 835 imports;HL7. All subscriptions come with the expert help of CrisSoft Support. Willing to partner/intergrate with all EMR's through REST.Starting Price: $249.00 -
4
Foothold
Foothold Technology
Our human services software offers full functionality for case management, client tracking, electronic health record (EHR), and homeless information management (HMIS) all under one roof. We work with agencies across the spectrum of human services: including developmental disabilities, mental health, substance use disorder, homelessness, supportive housing, HCBS, and much more. Foothold is HIPAA-compliant mental health software, federally certified as an EHR, and offers full interoperability as you navigate the new landscape of care coordination and value-based care. Transform the way you provide care with nimble software and a partnership guided by experience. -
5
Pomelo Health
Pomelo Health
Pomelo Health is a leader in the patient engagement and management space in North America since 2012. Pomelo’s suite of products includes an all-in-one patient engagement platform, a waiting room solution, and a vaccination solution for COVID-19 and other immunization campaigns. Key features to Pomelo’s patient engagement platform include e-booking, email and text appointment reminders, e-forms, telemedicine, broadcasts, and secure messaging. With thousands of healthcare practices in North America using its software, Pomelo is proven to improve patient satisfaction and reduce no-shows. The Pomelo Health vaccination solution is used by governments in both the US and Canada as well as some of the largest pharmacy chains including Walmart Canada. -
6
Raintree
Raintree Systems
Running a successful therapy & rehab organization takes dedication, effort, and time. Hours spent on administrative tasks, billing, and planning can add up quickly, leaving you with little time to focus on the most important aspects of your practice. Taking on an Electronic Medical Records (EMR) system can help alleviate some of the burden and make the management of your practice more efficient. Raintree's EMR is the perfect solution for streamlining your practice's administrative duties while allowing you to focus on providing quality care to your clients. With Raintree's EMR, you can easily manage patient information and data, quickly generate reports, and easily access patient records. With our all-in-one solution, you’ll get the tools you need to streamline your therapy and rehab practice, improve patient care, and get back to doing what you love. Our electronic medical records solution is the most comprehensive and user-friendly EMR on the market. -
7
Clinicea
Clinicea
We're the best all-in-one, cloud-based, clinic management platform for growing, ambitious clinics. Clinicea is loved for its unique technology that can replicate paper to generate a super-specialised EMR for you. Deploy virtual assistants to get questionnaires filled, and consents signed. Already in use by 40 specialities across 5 continents. Engage 24x7. Deploy white labelled tools for Online Bookings, Patient Portals, Auto-Invoicing. There’s lots more. No apps, no downloads, just a click. Comprehensive, easy and does it all. Take a demo and see live what the next-generation technology can do for you.Starting Price: $59 per user per month -
8
AZZLY
AZZLY
AZZLY Rize is the premier clinical and business platform for addiction treatment and mental health organizations. As an all-in-one substance use disorder and mental health specific EHR, Patient Engagement and RCM platform, we serve small, medium, and large clinics. Key features for OUTPATIENT Programs include: scheduling, appointment reminder, Zoom telehealth, treatment plans, progress notes, assessments and surveys. For RESIDENTIAL programs: census, medication management, bed board, withdrawal management, DrFirst e-prescribing, EPCS, PDMP, labs. For all levels of care: alerts, patient engagement portal, electronic billing and claims submission built in. AZZLY Rize empowers your staff through its 5 star training and support services, its simplicity and automation. As a true all-in-one EHR/PM/RCM platform, improved compliance, workflow and accurate billing are achieved real-time. We proudly serve programs in over 33 states and are hosted in Microsoft Azure's private cloud network.Starting Price: $50/user/month -
9
NextGen Healthcare EHR
NextGen Healthcare
NextGen Healthcare provides ambulatory practices of all sizes award-winning solutions along with dedicated support and professional services. We align with your goals to achieve the success that results in healthier patients and happier providers. NextGen® Enterprise EHR offers your practice configurable clinical content, intuitive workflows, and an integrated patient experience platform that incorporates telehealth. With NextGen® Mobile, your providers’ smartphones become an extension of your EHR, which saves valuable time. Managed cloud hosting keeps your practice secure and makes upgrades easy, though on-premise options are also available. NextGen® Office is a cloud-based EHR designed to support your practice growth, save staff time, and increase patient volume. This fully integrated clinical and billing platform features specialty-specific EHR content, mobile accessibility, a revenue cycle management system, and a convenient patient portal. -
10
Caspio
Caspio
Caspio is the world's leading NO-CODE platform for building online database applications without coding. The all-in-one platform provides everything you need to digitally transform business operations and workflows. It includes an integrated cloud database, a visual application builder, enterprise-grade security, regulatory compliance, and scalable global infrastructure. See why Caspio is trusted by over 15,000 companies worldwide. Try it for FREE. As a pioneer in the cloud industry since early 2000, Caspio's database platform is an application development solution for organizations of all sizes and is able to support HIPAA. All Caspio plans are competitively priced and allow unlimited users.Starting Price: $90/month (Annual term) -
11
Practice-Web Dental
Practice-Web
Practice-Web is a desktop dental software that supports all types and sizes of organizations. Providing charting, billing, imaging, patient scheduling, and practice management modules, the solution enables users to view progress notes as well as plan treatments and upcoming appointments. Practice-Web offers a wide range of features that include automated reminders, mobile forms for patient registration and treatment consent, COVID19 bilingual screening forms, customizable prescriptions, referral slips, lab slips, text messaging to patients and multi-page scanning.Starting Price: $149/mon -
12
Medesk
Medesk
Ideal for medical practitioners and private clinics, it is a cloud-based platform that streamlines your practice workflow, helping you attract and retain more patients at a lower cost. Medesk offers video consultations, in-built EHR, a schedule integrated with Google Calendar and iCal, online booking and appointment reminders, powerful analytics, and payment and deposit options. Medesk has developed ready-made solutions for GPs, mental health, allied health, and hair loss practitioners. Medesk allows you to automate the patient engagement process with the following tools: – Transparent online booking with convenient time slots available –Adding patient contact details straight to their EHR for immediate use – Automated confirmation emails and textsright after booking – Schedule reminders to cut down on cancellations and DNAsStarting Price: $15.00/month -
13
EHR 24/7®
Office Ally
EHR 24/7 by Office Ally is a trusted electronic health record system used by more than 20,000 users. Its comprehensive patient charting and document management, real-time patient information, and customizable forms provide healthcare providers with an intuitive interface to manage patient care. By using EHR 24/7, providers can improve communication and collaboration between providers, leading to more accurate diagnoses and fewer errors. Its seamless integration with other Office Ally solutions also provides additional functionality such as patient intake, electronic prescription, etc. With no needed implementation, healthcare providers can use EHR 24/7 to treat and document patients today.Starting Price: $44.95 per month -
14
CureMD
CureMD
Transform your practice with CureMD's cloud-based Electronic Health Record in a way you never imagined before. With a powerful knowledge base, CureMD is built for usability, performance, and reliability. It delivers advanced features, previously available in systems costing thousands of dollars, at a fraction of the cost. Version 10g includes an iPad app that works delightfully. It is intuitive, simple, and enjoyable. You have complete access to your appointments, clinical reviews, patient notes, medical histories, and document manager - all bundled in one app. Integrated access across patient demographics, scheduling, electronic billing, administrative/financial reporting and workflow management connects front and back office operations, improves productivity eliminates reimbursement delays and communication barriers.Starting Price: $295 per month -
15
PracticeHarmony
Mahler Health
Practice Harmony is the premier practice management tool for running your healthcare practice. Our cloud-based practice management software solution streamlines your practice's operations and optimizes your workflow. Robust scheduling, advanced EHR, customized forms, patient dashboard, optimized voice-to-text, full RCM, TeleMedicine, TelePsychiatry, eRx, HIPAA Compliant CRM, and so much more. Streamlined operations require the perfect orchestration of efficient patient scheduling, proper documentation, and successful billing. Run your entire practice from scheduling to billing with just one log-in. Schedule a demo today to learn how you can bring Harmony to your Practice. -
16
Salesforce Agentforce Health
Salesforce
Agentforce Health, formerly Health Cloud, is Salesforce’s AI-first platform built specifically for healthcare organizations. It connects clinical and non-clinical data on a unified, healthcare-specific data model to create a complete patient and member view. The platform leverages pre-built and configurable AI agents to automate workflows and surface real-time insights. Health Cloud helps reduce staff burnout by streamlining administrative tasks and improving operational efficiency. It supports personalized patient engagement and accelerates time to care through intelligent automation. Interoperability features integrate EHR and third-party systems to ensure seamless data exchange. Agentforce Health empowers providers, payers, and public health agencies to deliver connected, compliant, and patient-centered care. -
17
SuiteDash
SuiteDash
Most business software products are ‘one trick’ solutions. This forces businesses to ‘cobble together’ many different software tools to accomplish their goals, which is time-consuming, inefficient, disorderly and expensive SuiteDash solves this problem by combining the most commonly used business tools into one cloud-based software platform where the tools are already pre-integrated and full of useful built-in automations. And, the entire platform can be 100% White Labeled to fit your brand! Using SuiteDash helps your business become more efficient, more organized, more professional & more profitable!Starting Price: $19.00/month -
18
98point6
98point6
98point6 offers on-demand primary care delivered by board-certified physicians via the ease of a mobile app. Our subscription-based service means you can get diagnosis and treatment or simply consult on a health issue from anywhere. So whether you’re on the go, home sick in bed or multi-tasking throughout your day, immediate care is available on your schedule. On-demand, text-based diagnosis and treatment. No appointments, no travel, no waiting rooms. Expert care from board-certified physicians. Get primary care anywhere, in any context. Not just digitizing the visit, but transforming the experience–we eliminate friction, elevate quality, and give unlimited access for a low flat fee. It’s a better path to health and wellness. Our clinic team uses a proprietary care delivery platform built to make the experience better for both the patient and the provider. Before, during, and after each visit, the platform supports patient safety, quality control, outcomes, etc.Starting Price: Free -
19
SimplePractice
SimplePractice
SimplePractice is a comprehensive electronic health record (EHR) and practice management software tailored for health and wellness professionals. Serving over 225,000 practitioners, it offers features such as integrated telehealth, customizable documentation templates, billing and insurance tools, and a secure client portal. Designed to streamline administrative tasks, SimplePractice enhances client care and supports the growth of private practices. Starting Price: $35.00/month/user -
20
Mend
Mend
Mend is an enterprise-grade patient engagement and telehealth platform designed to help healthcare organizations profitably scale their practice and care for more patients. Founded in 2014, Mend is on a mission to revolutionize healthcare delivery so that every patient can receive extraordinary care. Mend makes it easy for healthcare providers to securely and efficiently communicate with their patients and colleagues, without concerns of violating HIPAA compliance or misplacing patient information. Mend provides integrated in-office and virtual care experiences for over 100 specialties with more than 5 million patients. Mend's comprehensive platform works hand-in-hand with all major EHR and PMS software to facilitate more than 400,000 telehealth visits per month, increase patient satisfaction by up to 23%, reduce no-show rates as low as 4%, radically improve staff productivity, and help providers drive more revenue through better patient attendance. -
21
IntakeQ
IntakeQ
Remove the paperwork from your intake with IntakeQ, a web-based online intake form management software for health professionals. HIPAA compliant, IntakeQ lets health professionals share online case forms with their patients privately; thus, improving client onboarding. The platform also comes with e-signature support, questionnaire analytics, client notes and profile, automated appointment reminders, and a secure messaging portal.Starting Price: $49.90/month -
22
Bridge
BridgeInteract
Bridge delivers patient engagement technology designed with digital empathy to restore the human connection in healthcare while reducing friction for patients, physicians, and staff. Its unified platform brings together access, communication, intake, scheduling, and payments into a single, seamless digital experience that works inside the EHR. Unlike competitors that rely on autonomous automation, we prioritize the provider-patient relationship. We ensure technology supports the compassionate care provided by your staff, rather than erecting a barrier of bots between the patient and provider. By eliminating fragmented tools and unnecessary administrative work, Bridge helps care teams spend less time managing systems and more time focusing on patients. The result is a simpler, more intuitive experience that patients actually use, staff can manage with ease, and physicians trust — driving a measurable return on experience and efficiency across your organization.Starting Price: $500.00/month -
23
Mercury Medical
CrisSoft
Awarded among the Top 10 MPM and RCM solutions, Mercury Medical is a robust medical billing solution. With over 400 customizable reports, built in Scheduler and Patient Portal, Mercury Medical is the perfect solution for major billing, suitable for multiple specialties and RCM processes Mercury Medical is a reliable, proven professional Accounts Receivable solution that will reduce processing times, shorten payment cycles and increase cash flow. Mercury Medical is fully configurable to any vertical or process including: Anesthesiology, University, Physical Therapy, and more. Mercury Products are HIPAA compliant with a guaranteed connection to any clearinghouse or insurance company. Mercury Medical’s automated job system will facilitate a daily system tune-up: housecleaning; folder maintenance; daily backups; 837 exports; 835 imports; HL7. All subscriptions come with the expert help of CrisSoft Support.Starting Price: $440.00 -
24
CarePaths EHR
CarePaths
We built CarePaths EHR for psychiatrists, psychologists, social workers, and counselors to affordably manage practices of all sizes. We are a HIPAA Compliant and ONC-Certified, fully integrated cloud-based behavioral electronic health record and practice management platform. Our system also includes online therapy with secure texting, teletherapy, and outcomes monitoring. With the free upgrade to CarePaths Connect, clinicians can also create a Digital Front Door, allowing patients to effortlessly sign up for services and book appointments with the CarePaths Connect mobile app for patients. Patients can also use the app to engage in teletherapy, message their therapist, and complete assessments. The Automated Measurement-Based Care (MBC) feature streamlines the process of outcomes monitoring so clinicians can tailor their approach based on patient feedback for better therapy outcomes.Starting Price: $49 per user per month -
25
ZENTAKE
ZENTAKE
The smartest way to manage your patient documents. ZENTAKE removes the hassle of managing paper intake documents. It is the perfect electronic intake and consent management platform for your staff and patients. Securely encrypted so you can collect and manage sensitive health data and keep your peace of mind. Save time and money by automating previously time-consuming intake management tasks. Solve your intake management problems forever by taking your form processes digital. Getting up and running is easier than you think. Start sending forms in minutes. ZENTAKE is designed to save your team and patients the headache of paper forms. It doesn't matter if patients complete their forms at home or in your office, ZENTAKE's intake tools help streamline your operations, while giving patients the safe, contactless options they want and you the specific information you need.Starting Price: $49/month -
26
Everleagues
Everleagues
Work remotely and collaborate with your team and clients. Create your firm’s own private workspace in minutes. Bring all the tools you need to one location and enhance your productivity while working remotely. EverLeagues seamlessly connects your company’s internal and external users to collaborate on day-to-day tasks in a secure platform, resulting in better service, saved time, and lowered costs. Collaborate through multiple channels, groups, and teams among employees, clients, and other contacts. Communicate with secure messaging, video conference, and file sharing. Everleagues provides security to all your files and messages without compromising productivity. Organize and manage your business or organization with a role and tier based organizational system. With Everleagues you can easily assign team members to specific organizations if you have different locations or departments. You can also assign specific clients to certain professionals or team members.Starting Price: $5.00 per user per month -
27
MediOffice
MediOffice
We are always open to ways to improve the software and welcome ideas. If you have an idea you would like to propose then please use our “Raise a Ticket” feature. Our training team are experts, not just at MediOffice but hugely experienced in the healthcare industry, and are happy to provide first-class training to you and your team. We have the experience, tools and expertise to successfully migrate your existing patient demographics and clinical history documentation from other practice management systems to MediOffice. To make the best use of your investment in MediOffice, it is essential that all the members of your team are properly trained. Our training team are experts, not just at MediOffice but hugely experienced in the healthcare industry. If you are looking to modernise your practice or have outgrown your current practice management software, we are here to provide a seamless migration to Medioffice.Starting Price: $113.99 per user per month -
28
Carepatron
Carepatron
Carepatron is a community-driven therapy scheduling platform for medical providers and their clients. They believe that healthcare teams play a critical role in our communities but often don't have access to the scheduling tools they need to deliver more collaborative and better mental health outcomes. Instead, they often rely on low-quality scheduling tools, manual processes, and legacy software to get by. Carepatron believes that the best way to better health is by bringing practitioners and clients together in one collaborative therapy platform. Carepatron features a free basic option, while the professional plan costs $12/month. An organizational account is also available. Key features: Online scheduling Calendar sync Recurring appointments SMS and Email reminders Website and Facebook calendar integration Fully integrated telehealth tool Health records, clinical notes, and documentation Payment processing HIPAA certifiedStarting Price: $0 -
29
Rallyest
Rallyest
Imagine having a way to support someone in treatment with a mobile secure and user-friendly tool. Wouldn’t it be amazing to have the ability to rally a client’s professional team and their natural network of support to increase the likelihood of lasting treatment success? You can give clients your best with Rallyest. Rallyest is pleased to announce the addition of video capabilities to the must-have line-up of features. By using a smartphone or computer, Rallyest captures secure video to share with a client, their support network, as well as their professionals. Making improved and confidential input, support, and connection possible for those in treatment settings. Engage clients, involve their support network, and boost treatment success for everyone. Rally a client’s extended network of select family, friends, co-workers, clergy, and professionals. Enjoy one location for a client’s photos, videos, updates, files, posts, comments, notifications, announcements, etc.Starting Price: Free -
30
MedTunnel
MedTunnel
MedTunnel salutes our frontline healthcare heroes in the fight against COVID-19. We are proud to have our free HIPAA-compliant messaging support you in this fight! MedTunnel is a free service that provides secure HIPAA-compliant communication for healthcare. It allows providers and patients to communicate and exchange private health information using their computers and mobile devices. The main purpose of MedTunnel is to provide a free, secure, and HIPAA-compliant messaging service for transmitting private health information (PHI) through the Internet. The core architecture of our product was designed to meet HIPAA and security guidelines. MedTunnel provides a secure conduit through the Internet for PHI transmission. In fact, our security protocol is such that no one at MedTunnel, even at the CEO level can access PHI even if they wanted to. Message instantly and securely with your office staff, other providers, other practices, or your patients, using any device, anywhere, anytime.Starting Price: Free
