Search Results for "pharmacokinetic"

These R packages are developed for data analysis of PK/PD modeling & simulation, bioequivalence/bioavailability (BE/BA), drug stability, in-vitro and in-vivo correlation (ivivc), as well as therapeutic drug monitoring (TDM).

ATLAS mPBPK is a MATLAb-based tool for modeling and Simulation of minimal Physiology Based Pharmacokinetic (mPBPK) models of small and large molecules. The tool enables the users to perform: i) PK data visualization, ii) simulation, iii) parameter optimization, and iv) local sensitivity analysis (SA) of mPBPK models in a simple and efficient manner.

The purpose of the current project is the development of a potentially open-source platform that would provide the capability to conduct virtual bioequivalence trial simulations. Ideally, this user-friendly platform will provide the user with many user-defined capabilities. Algorithm implementation for population pharmacokinetic analysis: The current project describes the marriage between PBPK modeling and population-based statistical analysis. The latter is necessary for parameter estimation when individual-level data is available. A critical aspect of this coupling is the implementation of an algorithm that would allow the performance of population-based statistical analysis. ...

Computationally predicts the pharmacokinetic properties of drug candidates using Quantitative Structure Property Relationships (QSPR) modelling. Assembles a set of tools and databases for predicting the physical properties of small molecules. The program models a given property's dependence on a collection of molecular and structural descriptors using a training set of molecules.

In order to maximise model based understanding of pharmacokinetic-pharmacodynamic (PKPD) studies, it is essential to choose sensible dosages and sampling times for experiments. PopED lite can help you improve your experimental design by algorithmically searching through possible experimental designs and suggesting the optimal experimental design. The algorithm is based on mathematically sound optimal design theory; however, PopED lite is made for users without any background in optimal design or mathematics. ...

The pkin package provides a font and a set of LaTeX commands to typeset symbols that can be useful in compartmental pharmacokinetic analysis.

PKgraph, provides a graphical user interface for population pharmacokinetic model diagnosis. It is programmed in R, and uses the R packages lattice, ggplot2 for static graphics, and rggobi for interactive graphics.

Census, formerly NONMEMory, is a project manager for population pharmacokinetic and pharmacodynamic analysis using the nonlinear mixed-effect modelling application NONMEM.

A reporting pipeline for checking population pharmacokinetic model assumption

Linstanpunmp is a linux port of the dos program STANPUMP. This program is used to drive a computer controlled infusion pump using a pharmacokinetic/pharmacodynamic model.

...Modern model-based approaches can be useful in drug concentration-effect establishment, preceded by the estimation of active concentrations of drugs. With specifically cardiac safety and efficacy assessment in mind, we developed a mechanistic physiologically based pharmacokinetic (PBPK) model of the heart useful in assessment of the cardiac active drug fraction surrogate responsible for the clinically observed drug-related electrophysiological response in humans. The PBPK models were developed for a parent compound and its metabolite and include inter-subject variability. The models were written in R v.3.4.0. ...