Evo 2 Integrations

GitHub is the world’s most secure, most scalable, and most loved developer platform. Join millions of developers and businesses building the software that powers the world. Build with the world’s most innovative communities, backed by our best tools, support, and services. If you manage multiple contributors , there’s a free option: GitHub Team for Open Source. We also run GitHub Sponsors, where we help fund your work. The Pack is back. We’ve partnered up to give students and teachers free access to the best developer tools—for the school year and beyond. Work for a government-recognized nonprofit, association, or 501(c)(3)? Get a discounted Organization account on us.

Hugging Face is a leading platform for AI and machine learning, offering a vast hub for models, datasets, and tools for natural language processing (NLP) and beyond. The platform supports a wide range of applications, from text, image, and audio to 3D data analysis. Hugging Face fosters collaboration among researchers, developers, and companies by providing open-source tools like Transformers, Diffusers, and Tokenizers. It enables users to build, share, and access pre-trained models, accelerating AI development for a variety of industries.

BioNeMo is an AI-powered drug discovery cloud service and framework built on NVIDIA NeMo Megatron for training and deploying large biomolecular transformer AI models at a supercomputing scale. The service includes pre-trained large language models (LLMs) and native support for common file formats for proteins, DNA, RNA, and chemistry, providing data loaders for SMILES for molecular structures and FASTA for amino acid and nucleotide sequences. The BioNeMo framework will also be available for download for running on your own infrastructure. ESM-1, based on Meta AI’s state-of-the-art ESM-1b, and ProtT5 are transformer-based protein language models that can be used to generate learned embeddings for tasks like protein structure and property prediction. OpenFold, a deep learning model for 3D structure prediction of novel protein sequences, will be available in BioNeMo service.

Evo Designer is an advanced tool developed by the Arc Institute, leveraging the capabilities of the Evo 2 genomic foundation model to facilitate DNA sequence generation and analysis. This platform enables users to input nucleotide sequences or specify organisms, prompting the model to generate corresponding DNA sequences. It provides comprehensive annotations of coding regions and, for prokaryotic sequences, offers 3D protein visualizations utilizing ESMFold. Additionally, Evo Designer evaluates sequences by scoring their perplexity and per-nucleotide entropy, assisting researchers in assessing sequence complexity and variability. The underlying Evo 2 model is trained on over 9 trillion nucleotides from a diverse array of prokaryotic and eukaryotic genomes, employing a deep learning architecture that models biological sequences at single-nucleotide resolution with a context window extending up to 1 million tokens.