Microsoft Defender for Endpoint vs. VMware vDefend ATP Comparison Chart

ESET Protect Advanced is a comprehensive cybersecurity solution designed for businesses of all sizes. It offers advanced endpoint protection against ransomware, zero-day threats, and sophisticated attacks with ESET LiveSense technology. It includes full disk encryption for legal compliance and data protection. The solution features proactive cloud-based threat defense using adaptive scanning, machine learning, cloud sandboxing, and behavioral analysis to prevent new threats. Mobile threat defense secures Android and iOS devices with anti-malware, anti-theft, and mobile device management. It also provides cloud app protection, mail server security, and vulnerability and patch management. Extended detection and response (XDR) enhances threat detection and response, while multi-factor authentication adds security. The solution offers single-pane-of-glass remote management for visibility into threats and users, along with advanced reporting and custom notifications.

The ThreatLocker suite of security tools are powerful and designed so that everyone from businesses to government agencies to academic institutions can directly control exactly what applications run on their networks. We envision a future in which all organizations can chart their own course free from the influence of cybercriminals and the damage their incursions cause, and our team of veteran cybersecurity professionals created ThreatLocker to make this vision a reality. The team at ThreatLocker has been developing cybersecurity tools for decades, including programs to enhance email and content security, and this is our most innovative and ambitious cybersecurity solution yet. We developed this unique cybersecurity system because we believe that organizations should have complete control of their networks and should not have to live in fear of the next malware attack. To learn more, visit ThreatLocker.com.

Guardz is the unified cybersecurity platform purpose-built for MSPs. We consolidate the essential security controls, including identities, endpoints, email, awareness, and more, into one AI-native framework designed for operational efficiency. Our identity-centric approach connects the dots across vectors, reducing the gaps that siloed tools leave behind so MSPs can see, understand, and act on user risk in real time. Backed by an elite research and threat hunting team, Guardz strengthens detection across environments, turning signals into actionable insights. With 24/7 AI + human-led MDR, Guardz utilizes agentic AI to triage at machine speed while expert analysts validate, mitigate, and guide response, giving MSPs scalable protection without adding headcount. Our mission is simple: give MSPs the scale, confidence, and clarity they need to stay ahead of attackers and deliver protection to every SMB they serve.

Cynet empowers MSPs and MSSPs with a comprehensive, fully managed cybersecurity platform that consolidates essential security functions into a single, easy-to-use solution. Cynet simplifies cybersecurity management, reduces operational overhead, and lowers costs by eliminating the need for multiple vendors and complex integrations. The platform provides multi-layered breach protection, offering robust security for endpoints, networks, and SaaS/Cloud environments. Cynet’s advanced automation streamlines incident response, ensuring rapid detection, prevention, and resolution of threats. Additionally, the platform is backed by Cynet’s 24/7 Security Operations Center (SOC), where the expert CyOps team delivers around-the-clock monitoring and support to safeguard all client environments. By partnering with Cynet, You can offer your clients advanced, proactive cybersecurity services while optimizing efficiency. Discover how Cynet can transform your security offerings today.

ConnectWise SIEM (formerly Perch) offers threat detection and response backed by an in-house Security Operations Center (SOC). Defend against business email compromise, account takeovers, and see beyond your network traffic. Our team of threat analysts does all the tedium for you, eliminating the noise and sending only identified and verified treats to action on. Built with multi-tenancy, ConnectWise SIEM helps you keep clients safe with the best threat intel on the market.

Action1 is an autonomous endpoint management platform that is cloud-native, infinitely scalable, highly secure, and configurable in 5 minutes—it just works and is always free for the first 200 endpoints, with no functional limits. By pioneering autonomous OS and third-party patching - AEM’s foundational use case - through peer-to-peer patch distribution and real-time vulnerability assessment without needing a VPN, it eliminates costly, time-consuming routine labor, preempts ransomware and security risks, and protects the digital employee experience. Trusted by thousands of enterprises managing millions of endpoints globally, Action1 is certified for SOC 2 and ISO 27001. The company is founder-led by industry veterans Alex Vovk and Mike Walters, American entrepreneurs who founded Netwrix, which has grown into a multibillion-dollar industry-leading cybersecurity company.

Cyber threats are everywhere, but protecting your IT systems should be as natural as locking your front door. With DriveLock’s HYPERSECURE Platform, safeguarding your endpoints and business data is easier than ever. We integrate the latest security technologies and share our expertise, so you can focus on what matters—without worrying about data protection. Zero Trust Platform takes a proactive approach, eliminating security gaps before they become a risk. By enforcing centralized policies, DriveLock ensures employees and endpoints access only what they need—following the golden rule of cybersecurity: ''never trust, always verify''.

Cisco Duo is a cloud-based identity security solution that protects organizations from identity-based threats and boosts workforce productivity. Trusted by over 40,000 organizations worldwide, Duo delivers an exceptional access management experience across all users, devices, and applications, making access to resources secure, seamless, and easy. Duo with Cisco Identity Intelligence provides deep visibility across your identity ecosystem, adding a powerful security layer to any identity infrastructure. Offer users a world-class access experience through Duo Passport to eliminate MFA friction and fatigue without sacrificing security. To stop threats, Duo verifies user identities with strong authenticators including Duo passwordless, Verified Duo Push with number matching, and phishing-resistant factors like biometrics and FIDO2 security keys. Paired with deep insights into users’ devices, Duo gives you the control to adaptively limit access based on device health or user risk.

Syncro offers the first Extended Monitoring and Management (XMM) platform purpose-built for midsized MSPs and internal IT teams. The unified platform integrates RMM (endpoint management), professional services automation (PSA), and Microsoft 365 multi-tenant management to help organizations simplify operations, strengthen security, and scale profitably. Syncro delivers powerful automation, native AI capabilities, deep Microsoft 365 integration, and seamless support for 50+ third-party tools—enabling teams to reduce complexity, cut costs, and uncover new revenue opportunities. Its transparent per-user pricing model and commitment to continuous innovation make it an ideal solution for modern IT operations. Learn more at syncromsp.com or follow Syncro on LinkedIn.

NinjaOne automates the hardest parts of IT, delivering visibility, security, and control over all endpoints for more than 20,000 customers. The NinjaOne automated endpoint management platform is proven to increase productivity, reduce security risk, and lower costs for IT teams and managed service providers. The company seamlessly integrates with a wide range of IT and security technologies. NinjaOne is obsessed with customer success and provides free and unlimited onboarding, training, and support.