ManageEngine Application Control Plus vs. USB-LOCK-RP Comparison Chart

ManageEngine Endpoint Central is built to secure the digital workplace while also giving IT teams complete control over their enterprise endpoints. It delivers a security-first approach by combining advanced endpoint protection with comprehensive management, allowing IT teams to manage the entire endpoint lifecycle, all from a single console. With automated patching across Windows, Mac, Linux and 1,000+ third-party applications, it ensures vulnerabilities are mitigated before attackers can exploit them. Its next-gen antivirus (NGAV) feature, powered by AI-driven behavioural detection, provides 24/7 protection against ransomware, malware, and zero-day threats. Endpoint Central further strengthens enterprise defenses with a broad set of security capabilities, including vulnerability assessment and mitigation, peripheral device control, data loss prevention, application control, endpoint privilege management, encryption with FileVault and BitLocker, and browser security.

The ThreatLocker suite of security tools are powerful and designed so that everyone from businesses to government agencies to academic institutions can directly control exactly what applications run on their networks. We envision a future in which all organizations can chart their own course free from the influence of cybercriminals and the damage their incursions cause, and our team of veteran cybersecurity professionals created ThreatLocker to make this vision a reality. The team at ThreatLocker has been developing cybersecurity tools for decades, including programs to enhance email and content security, and this is our most innovative and ambitious cybersecurity solution yet. We developed this unique cybersecurity system because we believe that organizations should have complete control of their networks and should not have to live in fear of the next malware attack. To learn more, visit ThreatLocker.com.

Airlock Digital is an application control solution that enforces a Deny by Default security posture. It enables organizations to define trusted applications, scripts, libraries, and processes at a granular level using file hash, path, publisher, or parent process. Only those explicitly defined as trusted are allowed to execute. The platform supports Windows, macOS, and Linux systems, including legacy operating systems and operational technology (OT) environments. Airlock Digital includes allowlisting and blocklisting capabilities, integrated file reputation checks via VirusTotal, and detailed logging for audit and compliance. Exception management is supported through features such as rule-based overrides and time-bound One-Time Passwords (OTPs). Centralized policy management allows consistent enforcement across large and distributed environments. The platform is available as an on-premises deployment, in the cloud, or as a managed hosted service.

Cyber threats are everywhere, but protecting your IT systems should be as natural as locking your front door. With DriveLock’s HYPERSECURE Platform, safeguarding your endpoints and business data is easier than ever. We integrate the latest security technologies and share our expertise, so you can focus on what matters—without worrying about data protection. Zero Trust Platform takes a proactive approach, eliminating security gaps before they become a risk. By enforcing centralized policies, DriveLock ensures employees and endpoints access only what they need—following the golden rule of cybersecurity: ''never trust, always verify''.

UTunnel provides Cloud VPN, ZTNA, and Mesh Networking solutions for secure remote access and seamless network connectivity. ACCESS GATEWAY: Our Cloud VPN as a Service offers swift deployment of Cloud or On-Premise VPN servers. It utilizes OpenVPN and IPSec protocols, enables policy-based access control, and lets you deploy a Business VPN network effortlessly. ONE-CLICK ACCESS: A Zero Trust Application Access (ZTAA) solution that simplifies secure access to internal business applications. It allows users to securely access them via web browsers without the need for a client application. MESHCONNECT: This Zero Trust Network Access (ZTNA) and mesh networking solution based on WireGuard enables granular access controls to business network resources and easy creation of secure mesh networks. SITE-TO-SITE VPN: The Access Gateway solution lets you easily set up secure Site-to-Site tunnels (IPSec) between UTunnel's VPN servers and hardware network gateways, firewalls & UTM systems.

Iru (formerly Kandji) is an all-in-one, AI-powered security and compliance platform designed to simplify IT management and strengthen enterprise protection. Built on the Iru Context Model, it unifies identity, endpoint, and compliance into a single intelligent system that understands users, devices, and applications in context. With passwordless workforce identity, advanced endpoint detection, and automated compliance, Iru delivers both security and efficiency without the complexity of multiple tools. Its integrated approach enables IT teams to secure access, prevent threats, and maintain continuous audit readiness—all from one intuitive platform. Trusted by over 5,000 companies including Plaid, Notion, Airbus, and Vercel, Iru transforms how modern businesses manage digital trust. The result is reduced IT workload, improved employee experience, and enterprise-grade protection built for the AI era.

ESET Protect Advanced is a comprehensive cybersecurity solution designed for businesses of all sizes. It offers advanced endpoint protection against ransomware, zero-day threats, and sophisticated attacks with ESET LiveSense technology. It includes full disk encryption for legal compliance and data protection. The solution features proactive cloud-based threat defense using adaptive scanning, machine learning, cloud sandboxing, and behavioral analysis to prevent new threats. Mobile threat defense secures Android and iOS devices with anti-malware, anti-theft, and mobile device management. It also provides cloud app protection, mail server security, and vulnerability and patch management. Extended detection and response (XDR) enhances threat detection and response, while multi-factor authentication adds security. The solution offers single-pane-of-glass remote management for visibility into threats and users, along with advanced reporting and custom notifications.

NinjaOne automates the hardest parts of IT, delivering visibility, security, and control over all endpoints for more than 20,000 customers. The NinjaOne automated endpoint management platform is proven to increase productivity, reduce security risk, and lower costs for IT teams and managed service providers. The company seamlessly integrates with a wide range of IT and security technologies. NinjaOne is obsessed with customer success and provides free and unlimited onboarding, training, and support.

Guardz is the unified cybersecurity platform purpose-built for MSPs. We consolidate the essential security controls, including identities, endpoints, email, awareness, and more, into one AI-native framework designed for operational efficiency. Our identity-centric approach connects the dots across vectors, reducing the gaps that siloed tools leave behind so MSPs can see, understand, and act on user risk in real time. Backed by an elite research and threat hunting team, Guardz strengthens detection across environments, turning signals into actionable insights. With 24/7 AI + human-led MDR, Guardz utilizes agentic AI to triage at machine speed while expert analysts validate, mitigate, and guide response, giving MSPs scalable protection without adding headcount. Our mission is simple: give MSPs the scale, confidence, and clarity they need to stay ahead of attackers and deliver protection to every SMB they serve.

Syncro offers the first Extended Monitoring and Management (XMM) platform purpose-built for midsized MSPs and internal IT teams. The unified platform integrates RMM (endpoint management), professional services automation (PSA), and Microsoft 365 multi-tenant management to help organizations simplify operations, strengthen security, and scale profitably. Syncro delivers powerful automation, native AI capabilities, deep Microsoft 365 integration, and seamless support for 50+ third-party tools—enabling teams to reduce complexity, cut costs, and uncover new revenue opportunities. Its transparent per-user pricing model and commitment to continuous innovation make it an ideal solution for modern IT operations. Learn more at syncromsp.com or follow Syncro on LinkedIn.