Showing 2 open source projects for "pharmacokinetics"

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  • 1

    Cluster Newton Method

    Source code for the Cluster Newton method

    Source codes for the Cluster Newton method presented at Aoki, Hayami, De Sterck, and Konagaya. Cluster Newton Method for Sampling Multiple Solutions of Underdetermined Inverse Problems: Application to a Parameter Identification Problem in Pharmacokinetics, SIAM J. Sci. Comput., 36(1), B14–B44. (31 pages) http://epubs.siam.org/doi/abs/10.1137/120885462 This is a personal version of the first author. For the official version and licence please visit http://konagaya-lab.sakura.ne.jp/jp...
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  • 2

    CardiacPBPK

    User Interface (ui) application which implements PBPK models

    Prediction of drug effect is valuable in terms of both safety and efficacy. Modern model-based approaches can be useful in drug concentration-effect establishment, preceded by the estimation of active concentrations of drugs. With specifically cardiac safety and efficacy assessment in mind, we developed a mechanistic physiologically based pharmacokinetic (PBPK) model of the heart useful in assessment of the cardiac active drug fraction surrogate responsible for the clinically observed...
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